Since you have a manual trans, use about 3/4 throttle and shift as early as you can without lugging the engine. If you're accellerating too quick using this method, shift earlier. If you need to accellerate quicker, shift a few hundred rpm higher.
Skipping gears isn't great for FE because you have to rev the engine a little higher in the low gears, which is a double hit to FE since you're spending more time in a lower gear, and you're reving the engine higher than optimal.
In my car I try to shift around 1500 rpm. This gives me plenty of accelleration for normal driving conditions, and I don't hold up anyone behind me. Accellerating and shifting this way feels odd at first, but you'll get used to it.
And another vote for this advice. That's almost exactly the approach I take.