In my 3000 pound VW with 195/65-15 tires, 51psi provides crisp, sure handling with decent ride. Your Ranger probably weighs about the same, if it's a 2WD 5 speed 4 cylinder regular cab. Your tires are probably 205/70-15, I'm guessing? If so, 44 would probably be about perfect, if the ride and handling are ok. You may need less in the rear.
I bet your tires are rated for a maximum of 44 and you should not exceed that anyway.
My full size pickup wears E-rated tires, good for 80psi. I can run 80 in the front but not much more than 70 in the rear.
Comfort doesn't suffer from my increased inflation in any of my vehicles. Handling, durability, and wear are significantly improved for me in addition to fuel savings. YMMV.
If you're already running the tires at the max sidewall pressure, its not recommended that you put that much more in them. That being said, the sidewall pressure for my Buick's tires is 35, but the tires wear even at 40 so that's where I keep them. That's the most important thing. If you cause abnormal wear, and have to prematurely replace your tires, any fuel savings you get will be more than made up for with increased tire replacements.