I think we do have one Durango driver.
I disagree about the nitrogen but I agree about the inflation. Air is already 78% nitrogen to begin with, and if (as nitrogen proponents say) nitrogen is the only part of air that doesn't seep through the tire, then after you top off the tire a few times there should be 95% nitrogen in there anyway. However, if you can get it for free then go ahead...it sure won't hurt anything.
The important part about that is the increased inflation. Chances are you'll never notice any loss in ride quality or traction, and in fact it will probably handle better. However, try to notice how braking, accelerating, and turning feel different to make sure it's safe, and after a few thousand miles try to notice if it's affecting the way your tires wear. Assuming you don't have any severe loss with those, inflating to the maximum rated pressure will probably provide a decent increase in fuel economy.
Of course there's strategies like not braking (for example, instead of powering up to a red light and then braking, roll up to it slowly and let it turn green before you stop) and not idling...and plenty of other strategies you can read about here by browsing the site.
This sig may return, some day.