As long as you wear them out, it doesn't matter -- you're driving 50,000 miles (or however long they last) no matter "how much you drive". If you never wear out tires, but have to replace them due to issues other than treadwear, then you certainly shouldn't spend more on LRR tires, or any decent tires -- I'd say you should buy used tires, or at least very cheap new ones.
I'd wonder how much more those tires cost. I'd save $210 dollars, according to that calculator, making them well worth buying instead of some other tires. Yes, I currently pump my tires up to 50psi, but I would do the same with those LRR tires.
I am happy to see any attempts at marketing LRR tires.