More than anything you need to ask yourself if the oem injectors and fuel pump can handle the increased supply that your altered fuel map will need to call for. A lot of turbo honda guys are running e85 but pay a pretty penny for the way larger pump, injectors, and injector driver.
I think about how SuspendedHatch found a tuner that could share his vision of a FE car. You'll need to do the same. A lot of people say that the octane rating of E85 is equivalent to 100 octane so in theory you can run a slightly leaner burn too but a competent tuner will need to determine a safe a/f ratio, as well as advice on what size injectors and pump will suffice.