Based on data from 17 vehicles, 1,185 fuel-ups and 441,818 miles of driving, the 2015 Mercedes-Benz E350 gets a combined Avg MPG of 22.49 with a 0.24 MPG margin of error.

Any Engine Type 3.5L V6 FLEX (3) 3.5L V6 GAS (12) V6 DIESEL (1) Any Body Style Sedan (2) Wagon (3) Any Submodel CDI AMG (1) Base (7) 4Matic (8) Other (1)

Below you can see a distribution of the fuel-ups with 145 outliers (10.90%) removed.

Following shows the average MPG of each of the 17 vehicles in the system.

• My E350

  2015 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Dec 2017 • 151 Fuel-ups

  Property of omarovii

• 21.2 Avg MPG

• My E350

  2015 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Apr 2024 • 4 Fuel-ups

  Property of GasHawk

• 19.2 Avg MPG

• MB E350

  2015 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Mar 2017 • 329 Fuel-ups

  Property of dckwan

• 22.0 Avg MPG

• 2015 MBZ Wagon

  2015 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed Wagon
  Added Aug 2023 • 39 Fuel-ups

  Property of TomBuddTX

• 24.6 Avg MPG

• Evelyn

  2015 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Apr 2023 • 35 Fuel-ups

  Property of mjfassio

• 26.0 Avg MPG

• 01 MB E350

  2015 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Mar 2017 • 113 Fuel-ups

  Property of drpiys

• 19.8 Avg MPG

• Merc'e

  2015 Mercedes-Benz E350 CDI AMG Automatic 9 Speed Sedan
  Added Oct 2015 • 95 Fuel-ups

  Property of seangee

• 33.3 Avg MPG

• My E350

  2015 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Mar 2020 • 28 Fuel-ups

  Property of myquestusa

• 21.8 Avg MPG

• My E350

  2015 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Jan 2021 • 23 Fuel-ups

  Property of lil754boy

• 24.0 Avg MPG

• Steph’s MB Wagon

  2015 Mercedes-Benz E350 4Matic 3.5L V6 FLEX Automatic 7 Speed
  Added Jan 2018 • 123 Fuel-ups

  Property of coonstz

• 20.6 Avg MPG

• My E350

  2015 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Aug 2018 • 98 Fuel-ups

  Property of Michael0057

• 24.7 Avg MPG

• Wagon Queen

  2015 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed Wagon
  Added Jan 2017 • 108 Fuel-ups

  Property of vasilythered

• 24.8 Avg MPG

• My E350

  2015 Mercedes-Benz E350 3.5L V6 FLEX Automatic 7 Speed
  Added Oct 2018 • 65 Fuel-ups

  Property of gorluc

• 21.1 Avg MPG

• E350

  2015 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added May 2017 • 67 Fuel-ups

  Property of veedubguy

• 22.2 Avg MPG

• Edna

  2015 Mercedes-Benz E350 Premium luxury V6 DIESEL Automatic 9 Speed
  Added Dec 2015 • 107 Fuel-ups

  Property of TheCRO

• 35.8 Avg MPG

• My E350

  2015 Mercedes-Benz E350 4Matic 3.5L V6 FLEX Automatic 7 Speed
  Added May 2018 • 4 Fuel-ups

  Property of rfcoolz

• 19.1 Avg MPG

• 2014 E350

  2015 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed Sedan
  Added Sep 2016 • 26 Fuel-ups

  Property of docdoodle

• 29.2 Avg MPG